288 research outputs found
Ubiquitous one-time password service using generic authentication architecture
Get PDFAbstract. In this paper we exploit GAA to build a scheme that converts a simple static password authentication mechanism into a one-time password (OTP) system. The scheme employs a GAA-enabled user device with a display and an input capability (e.g. a 3G mobile phone) and a GAA-aware server. Most importantly, the device does not need to be user or server specific, and can be used in the protocol with no registration or configuration (except for the installation of the necessary application software). The system also fits well to the multi-institution scenario and hence enables the provision of ubiquitous and on-demand OTP services. Keywords: One-time password, Generic Authentication Architecture, mobile securit
Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs
Get PDFStudies on the prevalence of risk factors and the incidence for cardiovascular diseases (CVDs) are limited in Kazakh population. By incorporating nomads, farmers, and urban residents, aged 30 years or older, in a cohort study, we investigated the characteristics of cardiovascular risk factors and their temporal trends that arose from the urbanization and subsequent changes in the lifestyle in a Kazakh population with 1668 participants. We used current guidelines and the monitoring trends and determinants in cardiovascular disease (MONICA) standard to define cardiovascular events. Kazakhs had a high prevalence rate of hypertension (45.3%), and this prevalence was much higher than the national average in China. Prevalence of two or more risk factors was highest among urban people and lowest among nomads. Urban residents have the highest prevalence of hypercholesterolemia and obesity compared with farmers and nomads. However, unlike other studies, our data indicate that young men had the highest prevalence of dyslipidemia, and it decreased significantly thereafter. Crude rates of incidence and mortality for acute cardiovascular events were 742 and 194 per 100,000 people, respectively; the standardized rates were 926 and 272 per 100,000 people, respectively. The findings from this study demonstrate the pervasive burden of cardiovascular risk factors and the related acute cardiovascular events in Kazakhs, particularly BP in Kazakh nomads
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1
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The primary cilium is a microtubule-based sensory organelle. The molecular mechanism that regulates ciliary dynamics remains elusive. Here, we report an unexpected finding that MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), blocks primary ciliary formation by inhibiting synthesis/assembly and promoting disassembly. This is mainly mediated by MLN4924-induced phosphorylation of AKT1 at Ser473 under serum-starved, ciliary-promoting conditions. Indeed, pharmaceutical inhibition (by MK2206) or genetic depletion (via siRNA) of AKT1 rescues MLN4924 effect, indicating its causal role. Interestingly, pAKT1-Ser473 activity regulates both ciliary synthesis/assembly and disassembly in a MLN4924 dependent manner, whereas pAKT-Thr308 determines the ciliary length in MLN4924-independent but VHL-dependent manner. Finally, MLN4924 inhibits mouse hair regrowth, a process requires ciliogenesis. Collectively, our study demonstrates an unexpected role of a neddylation inhibitor in regulation of ciliogenesis via AKT1, and provides a proof-of-concept for potential utility of MLN4924 in the treatment of human diseases associated with abnormal ciliogenesis.https://deepblue.lib.umich.edu/bitstream/2027.42/148214/1/13238_2019_Article_614.pd
Effects of rice or wheat residue retention on the quality of milled japonica rice in a rice–wheat rotation system in China
Get PDFAbstractIn rice–wheat rotation systems, crop straw is usually retained in the field at land preparation in every, or every other, season. We conducted a 3-year-6-season experiment in the middle–lower Yangtze River Valley to compare the grain qualities of rice under straw retained after single or double seasons per year. Four treatments were designed as: both wheat and rice straw retained (WR), only rice straw retained (R), only wheat straw retained (W), and no straw retained (CK). The varieties were Yangmai 16 wheat and Wuyunjing 23 japonica rice. The results showed contrasting effects of W and R on rice quality. Amylopectin content, peak viscosity, cool viscosity, and breakdown viscosity of rice grain were significantly increased in W compared to the CK, whereas gelatinization temperature, setback viscosity, and protein content significantly decreased. In addition, the effect of WR on rice grain quality was similar to that of W, although soil fertility was enhanced in WR due to straw being retained in two cycles. The differences in protein and starch contents among the treatments might result from soil nitrogen supply. These results indicate that wheat straw retained in the field is more important for high rice quality than rice straw return, and straw from both seasons is recommended for positive effects on soil fertility
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