74 research outputs found
Review of article-Cristina Hanganu-Bresch’s and Carol Berkenkotter’s “Narrative Survival: Personal and Institutional Accounts of Asylum Confinement.
Get PDFNo abstract available. Item is a review of the following journal article - Cristina Hanganu-Bresch and Carol Berkenkotter, “Narrative Survival: Personal and Institutional Accounts of Asylum Confinement.” Literature and Medicine 30.1 (2012): 12-41
Introduction - Screening Women’s Imprisonment: Agency and Exploitation in Orange is the New Black.
Get PDFIntroduction to the special edition of Television & New Media
Convict Voices: Women, Class and Writing about Prison in Nineteenth-Century England
Get PDFIn this lively study of the development and transformation of voices of female offenders in nineteenth-century England, Anne Schwan analyzes a range of colorful sources, including crime broadsides, reform literature, prisoners' own writings about imprisonment and courtroom politics, and conventional literary texts, such as Adam Bede and The Moonstone. Not only does Schwan demonstrate strategies for interpreting ambivalent and often contradictory texts, she also provides a carefully historicized approach to the work of feminist recovery. Crossing class lines, genre boundaries, and gender roles in the effort to trace prisoners, authors, and female communities (imagined or real), Schwan brings new insight to what it means to locate feminist (or protofeminist) details, arguments, and politics. In this case, she tracks the emergence of a contested, and often contradictory, feminist consciousness, through the prism of nineteenth-century penal debates. The historical discussion is framed by reflections on contemporary debates about prisoner perspectives to illuminate continuities and differences. Convict Voices offers a sophisticated approach to interpretive questions of gender, genre, and discourse in the representation of female convicts and their voices and viewpoints
Minorities on the Homefront: 'Enemy Alien' Internment in the British Empire 1914-1919. Education Learning Resource for use in Scottish prison learning centres.
Get PDFEducation resource containing materials and activities on internment camps during the First World War. Developed for schools in the context of a collaborative AHRC grant, by Rosemary Hannay and Stefan Manz. The version for use in prisons was modified by Anne Schwan and Kirsty Cameron as consultants
Postfeminism Meets the Women in Prison Genre: Privilege and Spectatorship in Orange Is the New Black
Get PDFThis article argues that Netflix’s original series Orange is the New Black (2013-), based on Piper Kerman’s memoir (2010), uses postfeminist strategies to covertly promote prison reform and exercise a subtle critique of (female) mass incarceration while renegotiating the boundaries of the women in prison genre in a neoliberal context of media production. Similar to earlier examples of the women in prison genre, OITNB highlights relationships between women, in this instance relationships between a particularly diverse group of women, with a view to interrogating white, middle-class women’s identity through Piper Chapman’s character, who also serves as a foil for the show’s implied viewer, at least initially. OITNB inhabits the tensions associated both with the women in prison genre and postfeminism, tensions manifesting themselves in titillating content and Netflix’s aggressive marketing campaigns, which appropriate women’s prison experiences as a life-style choice rather than focusing on in-depth analyses of the root causes of incarceration. Yet, the series has the potential to mobilize social awareness and activist sensibilities amongst its target audience, in a political and media environment where the individual and social cost of mass incarceration is increasingly recognized as untenable. Building on theories of postfeminism and recent work on the women in prison genre in feminist media, film and cultural studies, and by analyzing the show’s self-reflexive strategies and its exploration of Piper’s perspective, I suggest that the series affords useful opportunities for assessing the effectiveness of (post)feminism’s tactics as an ally in the fight against social inequalities, media (mis-)representation and mass imprisonment specifically
Lustspielabend: A Night at Stobs [Programme Brochure accompanying public performances]
Get PDFThis programme brochure was developed for audiences attending the 'A Night at Stobs' evening of theatre and music in Edinburgh, Glasgow and Hawick in June 2018. It contains information on the background to the performance, and the wider context of creativity in First World War internment camps, as well as details of the project team
The &Spaces Library
Get PDFCapstone project for LIS 2005 involving the redesign of public library institutions with a focus on physical space. Conference poster, PowerPoint, and paper attached
Plague and the Human Flea, Tanzania
Get PDFPulex irritans fleas were more common in villages with high plague incidence
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
Get PDFSteroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age. However, in many patients, the genetic etiology remains unknown. Here, we have performed whole exome sequencing to identify recessive causes of SRNS. In 7 families with SRNS and facultative ichthyosis, adrenal insufficiency, immunodeficiency, and neurological defects, we identified 9 different recessive mutations in SGPL1, which encodes sphingosine-1-phosphate (S1P) lyase. All mutations resulted in reduced or absent SGPL1 protein and/or enzyme activity. Overexpression of cDNA representing SGPL1 mutations resulted in subcellular mislocalization of SGPL1. Furthermore, expression of WT human SGPL1 rescued growth of SGPL1-deficient dpl1. yeast strains, whereas expression of disease-associated variants did not. Immunofluorescence revealed SGPL1 expression in mouse podocytes and mesangial cells. Knockdown of Sgpl1 in rat mesangial cells inhibited cell migration, which was partially rescued by VPC23109, an S1P receptor antagonist. In Drosophila, Sply mutants, which lack SGPL1, displayed a phenotype reminiscent of nephrotic syndrome in nephrocytes. WT Sply, but not the disease-associated variants, rescued this phenotype. Together, these results indicate that SGPL1 mutations cause a syndromic form of SRNS
Mutations in KEOPS-Complex Genes Cause Nephrotic Syndrome with Primary Microcephaly
Get PDFGalloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue. Furthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced apoptosis. Knockdown of OSGEP or TP53RK induced defects in the actin cytoskeleton and decreased the migration rate of human podocytes, an established intermediate phenotype of SRNS. We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms
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