946 research outputs found
Unreported summary statistics in trial publications and risk of bias in stroke rehabilitation systematic reviews: an international survey of review authors and examination of practical solutions
Get PDFThe Relation Between Galaxy ISM and Circumgalactic OVI Gas Kinematics Derived from Observations and CDM Simulations
Full text linkWe present the first galaxy-OVI absorption kinematic study for 20 absorption
systems (EW>0.1~{\AA}) associated with isolated galaxies (0.150.55) that
have accurate redshifts and rotation curves obtained using Keck/ESI. Our sample
is split into two azimuthal angle bins: major axis () and
minor axis (). OVI absorption along the galaxy major axis is
not correlated with galaxy rotation kinematics, with only 1/10 systems that
could be explained with rotation/accretion models. This is in contrast to
co-rotation commonly observed for MgII absorption. OVI along the minor axis
could be modeled by accelerating outflows but only for small opening angles,
while the majority of the OVI is decelerating. Along both axes, stacked OVI
profiles reside at the galaxy systemic velocity with the absorption kinematics
spanning the entire dynamical range of their galaxies. The OVI found in AMR
cosmological simulations exists within filaments and in halos of ~50 kpc
surrounding galaxies. Simulations show that major axis OVI gas inflows along
filaments and decelerates as it approaches the galaxy while increasing in its
level of co-rotation. Minor axis outflows in the simulations are effective
within 50-75 kpc beyond that they decelerate and fall back onto the galaxy.
Although the simulations show clear OVI kinematic signatures they are not
directly comparable to observations. When we compare kinematic signatures
integrated through the entire simulated galaxy halo we find that these
signatures are washed out due to full velocity distribution of OVI throughout
the halo. We conclude that OVI alone does not serve as a useful kinematic
indicator of gas accretion, outflows or star-formation and likely best probes
the halo virial temperature.Comment: 24 pages, 21 figures, 4 tables. Accepted to ApJ on November 14, 201
Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi
Get PDF10.1186/1471-2148-9-15BMC Evolutionary Biology911
Food Matters: Food Insecurity among Pregnant Adolescents and Infant Birth Outcomes
Get PDFObjectives: The objectives of this study are to: (1) document prevalence of food insecurity among pregnant adolescents; (2) determine if food insecurity is associated with adverse birth outcomes (i.e., lower birth weight, earlier gestational age) among their newborns; and (3) examine whether depressive symptoms, anxiety, nutrition and/or weight gain mediate these associations.
Methods: Pregnant adolescents (14-21 years old; N-881) in prenatal care at community hospitals and health centers in New York City completed a health and psychosocial survey during second and third trimesters of pregnancy. Birth weight and gestational age were recorded from medical records.
Results: Over one-half of the adolescents reported food insecurity. Path analyses demonstrated that food insecurity was associated with lower birth weight and earlier gestational age. Depressive symptoms mediated these associations.
Conclusions: Pregnant adolescents experience high rates of food insecurity. Those who were food insecure experienced more depressive symptoms, which in turn predicted adverse birth outcomes. Programs and policies should target these vulnerable children to stem the multi-generational effects of food insecurity
Measuring the association between body mass index and all-cause mortality in the presence of missing data: analyses from the Scottish national diabetes register:Missing data in the Scottish diabetes register
Get PDFAssessing alternate sparger configurations to mitigate supply chain risks in single-use bioreactors
Get PDFConsumable shortages throughout the pandemic introduced unanticipated challenges for continued manufacture of commercial biologics. With single-use systems, the bioreactors themselves are consumables that were impacted by these supply chain shortages. To ensure patient supply of necessary biologics, risk mitigation planning and determining suitable alternatives was required. In this presentation, we detail work performed to allow for continued manufacturing, while facing stock-out risks for single-use bioreactor bags used at both the seed and production stages. Specifically, this work focused on alternate sparger configurations, as the standard configuration used in the production bioreactor stage was unavailable. Additional options for added flexibility at the seed bioreactor stages were evaluated to address stock-out risks, and are discussed.
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Computability limits non-local correlations
Full text linkIf the no-signalling principle was the only limit to the strength of
non-local correlations, we would expect that any form of no-signalling
correlation can indeed be realized. That is, there exists a state and
measurements that remote parties can implement to obtain any such correlation.
Here, we show that in any theory in which some functions cannot be computed,
there must be further limits to non-local correlations than the no-signalling
principle alone. We proceed to argue that even in a theory such as quantum
mechanics in which non-local correlations are already weaker, the question of
computability imposes such limits.Comment: 5 pages, 1 figure, revte
Use of Coronary Computed Tomographic Angiography to guide management of patients with coronary disease
Get PDFBackground In a prospective, multicenter, randomized controlled trial, 4,146 patients were randomized to receive standard care or standard care plus coronary computed tomography angiography (CCTA). Objectives The purpose of this study was to explore the consequences of CCTA-assisted diagnosis on invasive coronary angiography, preventive treatments, and clinical outcomes. Methods In post hoc analyses, we assessed changes in invasive coronary angiography, preventive treatments, and clinical outcomes using national electronic health records. Results Despite similar overall rates (409 vs. 401; p = 0.451), invasive angiography was less likely to demonstrate normal coronary arteries (20 vs. 56; hazard ratios [HRs]: 0.39 [95% confidence interval (CI): 0.23 to 0.68]; p < 0.001) but more likely to show obstructive coronary artery disease (283 vs. 230; HR: 1.29 [95% CI: 1.08 to 1.55]; p = 0.005) in those allocated to CCTA. More preventive therapies (283 vs. 74; HR: 4.03 [95% CI: 3.12 to 5.20]; p < 0.001) were initiated after CCTA, with each drug commencing at a median of 48 to 52 days after clinic attendance. From the median time for preventive therapy initiation (50 days), fatal and nonfatal myocardial infarction was halved in patients allocated to CCTA compared with those assigned to standard care (17 vs. 34; HR: 0.50 [95% CI: 0.28 to 0.88]; p = 0.020). Cumulative 6-month costs were slightly higher with CCTA: difference 303 to $621). Conclusions In patients with suspected angina due to coronary heart disease, CCTA leads to more appropriate use of invasive angiography and alterations in preventive therapies that were associated with a halving of fatal and non-fatal myocardial infarction. (Scottish COmputed Tomography of the HEART Trial [SCOT-HEART]; NCT01149590
Quantitative measures of health policy implementation determinants and outcomes: A systematic review
Get PDFBACKGROUND: Public policy has tremendous impacts on population health. While policy development has been extensively studied, policy implementation research is newer and relies largely on qualitative methods. Quantitative measures are needed to disentangle differential impacts of policy implementation determinants (i.e., barriers and facilitators) and outcomes to ensure intended benefits are realized. Implementation outcomes include acceptability, adoption, appropriateness, compliance/fidelity, feasibility, penetration, sustainability, and costs. This systematic review identified quantitative measures that are used to assess health policy implementation determinants and outcomes and evaluated the quality of these measures.
METHODS: Three frameworks guided the review: Implementation Outcomes Framework (Proctor et al.), Consolidated Framework for Implementation Research (Damschroder et al.), and Policy Implementation Determinants Framework (Bullock et al.). Six databases were searched: Medline, CINAHL Plus, PsycInfo, PAIS, ERIC, and Worldwide Political. Searches were limited to English language, peer-reviewed journal articles published January 1995 to April 2019. Search terms addressed four levels: health, public policy, implementation, and measurement. Empirical studies of public policies addressing physical or behavioral health with quantitative self-report or archival measures of policy implementation with at least two items assessing implementation outcomes or determinants were included. Consensus scoring of the Psychometric and Pragmatic Evidence Rating Scale assessed the quality of measures.
RESULTS: Database searches yielded 8417 non-duplicate studies, with 870 (10.3%) undergoing full-text screening, yielding 66 studies. From the included studies, 70 unique measures were identified to quantitatively assess implementation outcomes and/or determinants. Acceptability, feasibility, appropriateness, and compliance were the most commonly measured implementation outcomes. Common determinants in the identified measures were organizational culture, implementation climate, and readiness for implementation, each aspects of the internal setting. Pragmatic quality ranged from adequate to good, with most measures freely available, brief, and at high school reading level. Few psychometric properties were reported.
CONCLUSIONS: Well-tested quantitative measures of implementation internal settings were under-utilized in policy studies. Further development and testing of external context measures are warranted. This review is intended to stimulate measure development and high-quality assessment of health policy implementation outcomes and determinants to help practitioners and researchers spread evidence-informed policies to improve population health.
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